High dose insulin therapy, an evidence based approach to beta blocker/calcium channel blocker toxicity
نویسندگان
چکیده
منابع مشابه
High-dose insulin therapy in beta-blocker and calcium channel-blocker poisoning.
INTRODUCTION. High-dose insulin therapy, along with glucose supplementation, has emerged as an effective treatment for severe beta-blocker and calcium channel-blocker poisoning. We review the experimental data and clinical experience that suggests high-dose insulin is superior to conventional therapies for these poisonings. PRESENTATION AND GENERAL MANAGEMENT. Hypotension, bradycardia, decrease...
متن کاملβ-Blocker and Calcium Channel Blocker Poisoning: High-Dose Insulin/Glucose Therapy.
Overdoses of β-blockers and calcium channel blockers can produce significant morbidity and mortality, and conventional therapies often do not work as treatments for these poisonings. High-dose insulin/glucose therapy has been successful in reversing the cardiotoxic effects of these drugs in cases where the standard therapies have failed, and it appears to be relatively safe. Many successes have...
متن کاملLipid Rescue Therapy and High-Dose insulin Euglycemic Therapy are Effective for Severe Refractory Calcium Channel Blocker Overdose: Case Report and Review of Literature
Background: High-Dose Insulin Euglycemic Therapy (HIET) and Lipid Rescue Therapy (LRT) are new alternative treatments for acute poisoning with calcium channel blockers. In this report a severely poisoned patient with verapamil and furosemide who was successfully treated with these two treatments is presented. Case report: A 27-year-old woman was brought to “Mother Theresa” Clinical Center in Sk...
متن کاملBeta-Blocker Overdose Treated with Extended Duration High Dose Insulin Therapy
Poisoning and overdose of beta-blockers may be associated with significant morbidity and mortality. Management is often complicated by failure of initial first-line interventions in severe ingestions. High-dose insulin, or hyperinsulinemia/euglycemia therapy has been well described in calcium channel blocker overdose as well as mixed ingestions of calcium channeland betablocker agents. The data...
متن کاملManagement of beta-adrenergic blocker and calcium channel antagonist toxicity.
State-of-the-art therapy for beta-adrenergic receptor blocker and calcium channel antagonist toxicity is reviewed in the light of new insights into drug-induced shock. A brief discussion of pathophysiology, including cardiac, hemodynamic, and metabolic effects of cardiac drug toxicity, provides a foundation for understanding the basis of therapy. The major focus of this review is a critical eva...
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ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2014
ISSN: 2008-2231
DOI: 10.1186/2008-2231-22-36